Four authors write about the Central Dogma without understanding it

One of the nice things about reading older scientists’ blogs and Twitter feeds is that you get reminded of things you should know and have your own views corrected from their years of experience. One of the things that I’ve seen Larry Moran, professor emeritus at the University of Toronto, write about repeatedly is the Central Dogma of Molecular Biology.

The Central Dogma is a concept that was described by Francis Crick, one of the two scientists who described the structure of DNA, and can be summarised by saying that sequence information can be transferred between nucleic acids or from nucleic acids to protein but never from protein to either protein or to nucleic acid. Or, in graphical form with arrows showing transfer of sequence information:

central-dogma-crick-1970

https://www.nature.com/nature/focus/crick/pdf/crick227.pdf

Continue reading